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CIALIS ORIGINAL

  • Indication: Erectile Dysfunction
  • Sale: With online prescription
  • Active Component: Tadalafil
  • Dosage: 20mg
  • Form: Yellow colored tablet
  • Start of Effects: 20 - 50 minutes
  • Effects duration: 36 hours

Effective in more than 95% of cases

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CIALIS GENERIC

  • Indication: Erection Problems
  • Sale: With online prescription
  • Active Component: Tadalafil
  • Dosage: 20mg
  • Form: Yellow colored tablet
  • Start of Effects: 20 - 50 minutes
  • Effects duration: 36 hours

A Cialis Generic pill costs around € 3.58

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CIALIS SOFT TABS

  • Indication: Enhance Erection
  • Sale: With online prescription
  • Active Component: Tadalafil
  • Dosage: 20mg
  • Form: Yellow dissolving tablets
  • Start of Effects: 15 - 20 minutes
  • Effects duration: Up to 36 hours

Buy Cialis Soft tabs with fast delivery

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TRIPLE TRIAL PACK

  • Indication: Treat impotence
  • Sale: With online prescription
  • Active Component: Tadalafil
  • Dosage: 10mg
  • Form: Chewable Tablets
  • Start of Effects: 15 - 20 minutes
  • Effects duration: Up to 36 hours

In pharmacies you can get this pills for € 2.99 per pill

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CIALIS PRICE

Cialis Original

  • PRODUCT DOSAGE QUANTITY PRICE ORDER
  • Cialis Original 20 4+2 € 69.00
  • Cialis Original 20 8+2 € 109.00
  • Cialis Original 20 12+4 € 149.00
  • Cialis Original 20 16+6 € 165.00
  • Cialis Original 20 20+6 € 189.00
  • Cialis Original 20 32+8 € 269.00

Cialis Generic

  • PRODUCT DOSAGE QUANTITY PRICE ORDER
  • Cialis Generic 20 12 € 79.00
  • Cialis Generic 20 16+2 € 99.00
  • Cialis Generic 20 20+4 € 126.00
  • Cialis Generic 20 30+6 € 149.00
  • Cialis Generic 20 50+10 € 215.00

Cialis Soft Tabs

  • PRODUCT DOSAGE QUANTITY PRICE ORDER
  • Cialis Soft Tabs 20 10+4 € 75.00
  • Cialis Soft Tabs 20 30+6 € 125.00
  • Cialis Soft Tabs 20 60+10 € 199.00
  • Cialis Soft Tabs 20 90+18 € 255.00

CIALIS EFFECTS & FORMULA

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Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil inhibits PDE5. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation.

The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum and pulmonary arteries is also observed in the smooth muscle of the prostate, the bladder and their vascular supply. The mechanism for reducing BPH symptoms has not been established.

Studies in vitro have demonstrated that tadalafil is a selective inhibitor of PDE5. PDE5 is found in the smooth muscle of the corpus cavernosum, prostate, and bladder as well as in vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas.

In vitro studies have shown that the effect of tadalafil is more potent on PDE5 than on other phosphodiesterases. These studies have shown that tadalafil is >10,000-fold more potent for PDE5 than for PDE1, PDE2, PDE4, and PDE7 enzymes, which are found in the heart, brain, blood vessels, liver, leukocytes, skeletal muscle, and other organs. Tadalafil is >10,000-fold more potent for PDE5 than for PDE3, an enzyme found in the heart and blood vessels. Additionally, tadalafil is 700-fold more potent for PDE5 than for PDE6, which is found in the retina and is responsible for phototransduction. Tadalafil is >9,000-fold more potent for PDE5 than for PDE8, PDE9, and PDE10. Tadalafil is 14-fold more potent for PDE5 than for PDE11A1 and 40-fold more potent for PDE5 than for PDE11A4, two of the four known forms of PDE11. PDE11 is an enzyme found in human prostate, testes, skeletal muscle and in other tissues (e.g., adrenal cortex). In vitro, tadalafil inhibits human recombinant PDE11A1 and, to a lesser degree, PDE11A4 activities at concentrations within the therapeutic range. The physiological role and clinical consequence of PDE11 inhibition in humans have not been defined. Click Here for More informations.

Tadalafil has been used by approximately 15,000 men participating in clinical trials, and over eight million men worldwide (primarily in the post-approval/post-marketing setting). The most common side effects when using tadalafil are headache, stomach discomfort or pain, indigestion, burping, acid reflux, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects reflect the ability of PDE5 inhibition to cause vasodilation (cause blood vessels to widen), and usually go away after a few hours. Back pain and muscle aches can occur 12 to 24 hours after taking the drug, and the symptom usually disappears after 48 hours.

In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) was associated with vision impairment related to NAION (non-arteritic anterior ischemic optic neuropathy) in certain patients taking these drugs in the post-marketing (outside of clinical trials) setting. Most, but not all, of these patients had underlying anatomic or vascular risk factors for development of NAION unrelated to PDE5 use, including: low cup to disc ratio ("crowded disc"), age over 50, diabetes, hypertension, coronary artery disease, hyperlipidemia and smoking. Given the small number of NAION events with PDE5 use (fewer than one in one million), the large number of users of PDE5 inhibitors (millions) and the fact that this event occurs in a similar population to those who do not take these medicines, the FDA concluded that they were not able to draw a cause and effect relationship, given these patients underlying vascular risk factors or anatomical defects. However, the label of all three PDE5 inhibitors was changed to alert clinicians to a possible association. cialis effects europe-pharm-en cialis_mob_2 -europe-pharm-en

TOP ARTICLES & LATEST NEWS

Cialis (Tadalafil) - is one of the most popular drugs against erectile dysfunction created by Icos and Elly Lilly companies. After the necessary clinical research the drug was approved by the European Union and in 2003 tadalafil appeared on the pharmaceutical market under the trade name "Cialis". Since then Cialis firmly have taken the 2-nd place as the most popular drug among erectile dysfunction medications, surrendering the first place only Viagra. However, many men consider Cialis to be much better than Viagra for two reasons:...

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Erectile dysfunction (ED) also known as impotence is an inability of a man to achieve and maintain erections sufficient for the accomplishment of a sexual intercourse. Inability of a person to have full-blown sexual relationships has a negative influence on all the spheres of his life, this is a problem which is impossible to ignore. This condition seldom occurs on its own, as a rule potency-related problems appear as a result of psychological problems or diseases. It is very important to identify the real cause of impotence, ...

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A total of 16 trials that compared tadalafil with sildenafil for the treatment of ED were included in the meta-analysis. In the meta-analysis, tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates. However, compared with sildenafil, tadalafil significantly improved psychological outcomes. Furthermore,...

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It’s no secret that oily coldwater fish like wild salmon, sardines, and tuna are overflowing with omega-3 fatty acids, but here’s something you may not know: The nutrient not only benefits your heart but also raises dopamine levels in the brain. This spike in dopamine improves circulation and blood flow, triggering arousal ...

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